By Vanessa Bates Ramirez
Heart disease is the leading cause of death in the US for both men and women. According to the Centers for Disease Control and Prevention, 735,00 Americans have a heart attack each year, and 610,000 die of heart disease.
Those who survive heart attacks remain at serious risk for heart failure. During a heart attack, the network of blood vessels that delivers blood to the heart, called the coronary arteries, experiences a blockage due to buildup of cholesterol and fatty deposits. Blood can’t flow through to the heart, which means it doesn’t get the oxygen and nutrients it needs, causing tissue to die.
Heart attack survivors are thus left with a heart that’s weaker, making everyday tasks like lifting objects or climbing stairs exhausting or even dangerous. Restoring damaged heart tissue has proved difficult if not impossible, but a research team from Imperial College London has a new tool they hope will be able to heal wounded hearts.
The team developed thumb-sized patches of heart tissue, about two by three centimeters in size and containing up to 50 million human stem cells. They programmed the stem cells to mature into working heart muscle, or cardiac progenitor cells. The patches are sewn onto the damaged area of the heart to help pump blood and release chemicals to stimulate repair and regeneration. The team presented its research at the British Cardiovascular Society (BCS) Conference in Manchester this week.
Using stem cells to treat weakened heart muscle isn’t a new concept. But many existing methods injected stem cells directly into damaged tissue, and without a ‘scaffold’ to hold them in place, the cells would clear out of the heart before achieving significant tissue repair.
The team tested the patches in rabbits, finding that four weeks after implanting a patch, the hearts’ left ventricles (the chamber that pumps blood to the body through the aorta) recovered without developing abnormal heart rhythms. They also found that blood vessels from recipient hearts grew into the patches and helped nourish them, a crucial step for integration. The patches started to beat spontaneously after just three days, and within one month started to mimic mature heart tissue.
The next step is to test the safety of the patches through clinical trials, then attempt to use them to repair human hearts.
“One day, we hope to add heart patches to the treatments that doctors can routinely offer people after a heart attack,” said Dr. Richard Jabbour, who carried out the research. “We could prescribe one of these patches alongside medicines for someone with heart failure, which you could take from a shelf and implant straight into a person.”
Professor Metin Avkiran, associate medical director at the British Heart Foundation, which funded the research, added “This is a prime example of world-leading research that has the potential to mend broken hearts and transform lives around the globe. If clinical trials can show the benefits of these heart patches in people after a heart attack, it would be a great leap forward for regenerative medicine.”